Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators - ScienceDirect
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS
The Ras switch in structural and historical perspective
The Ras switch in structural and historical perspective
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
Simulating Ras: 30 years of progress - NCI
The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology
Biomolecules | Free Full-Text | Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife
Potential for Next Generation RAS Inhibitors in Adult and Pediatric Cancers
A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation | PLOS ONE
The Ras switch in structural and historical perspective
Simulating Ras: 30 years of progress - NCI
Simulating Ras: 30 years of progress - NCI
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology
Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect
Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife
RAS(ON) Inhibitors | Revolution Medicines
Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports
Pharmaceuticals | Free Full-Text | A Rational Design of α-Helix-Shaped Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders
RAS(ON) Inhibitors | Revolution Medicines
RCSB PDB - 1U8Y: CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | bioRxiv
Structural Insights into the BRAF Monomer-to-dimer Transition Mediated by RAS Binding | bioRxiv
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain | Scientific Reports
